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Interaction of Riboflavin-5-Phosphate With Liposome Bilayers

Interaction of Riboflavin-5-Phosphate With Liposome Bilayers

Anju Gupta, Poornima Kalyanram, Istvan Stadler
Copyright: © 2018 |Volume: 3 |Issue: 1 |Pages: 11
ISSN: 2379-7452|EISSN: 2379-7444|EISBN13: 9781522547259|DOI: 10.4018/JNN.2018010103
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MLA

Gupta, Anju, et al. "Interaction of Riboflavin-5-Phosphate With Liposome Bilayers." JNN vol.3, no.1 2018: pp.49-59. http://doi.org/10.4018/JNN.2018010103

APA

Gupta, A., Kalyanram, P., & Stadler, I. (2018). Interaction of Riboflavin-5-Phosphate With Liposome Bilayers. Journal of Nanotoxicology and Nanomedicine (JNN), 3(1), 49-59. http://doi.org/10.4018/JNN.2018010103

Chicago

Gupta, Anju, Poornima Kalyanram, and Istvan Stadler. "Interaction of Riboflavin-5-Phosphate With Liposome Bilayers," Journal of Nanotoxicology and Nanomedicine (JNN) 3, no.1: 49-59. http://doi.org/10.4018/JNN.2018010103

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Abstract

Riboflavin presents tremendous potential as a photosensitizing agent for photodynamic therapy (PDT) for treating microbial infection and cancer therapy. Encapsulation of riboflavin can improve its bioavailability and stability while making the clinical applications more efficient. The authors' detailed study on cellular inhibition of liposome encapsulated riboflavin-5-phosphate investigation, and the effect of unencapsulated riboflavin on liposome bilayers aims to improve the efficiency of cellular delivery of riboflavin. Nano-sized liposomes composed of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and cholesterol were used in this study. Cell studies demonstrate high inhibition rates for the lipsome-encapsualted high concentration riboflavin formulations in the presence of blue light, despite the lower encapsulation lading.

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